Isabel Aretas, widow of drug kingpin Benito, escapes from a Mexican prison with the aid of her son Armando. Isabel sends Armando to Miami, tasking him with recovering a substantial stash of money his father Benito had hidden, as well as assassinating the people responsible for his father's arrest and eventual death in prison. Isabel demands that Armando should also kill Detective Mike Lowrey, who is settled in Miami. Mike accompanies his partner Marcus Burnett to the birth of his first grandson. Desiring to spend more time with his family, the aging Marcus tells Mike he intends to retire, to Mike's chagrin. During a party celebrating Marcus's grandson, Mike is shot by Armando and left in a coma for months. Chastised by Isabel for targeting Mike first, Armando continues to assassinate other targets on his list during Mike's convalescence.